Dukakis actively participated in first cousin Michael Dukakis' presidential campaign in 1988. She is a founding member of Voices of Earth, The National Museum of Women in the Arts, and a member of several outstanding organizations including Survivors of Torture, Broadway Cares, NOW, Women in Film, Congress of Racial Equality, and Amnesty International. She continues to be a popular speaker at women's expos and conferences throughout the United States and has participated in nationwide awareness campaigns on the issues of domestic abuse, osteoporosis, senior services, and cholesterol.

Dukakis lives in New York City with her husband, actor Louis Zorich. They have three children, Christina, Peter and Stefan and three grandchildren Isabella, Sofia and Luka.