For eighteen years Meryl Comer wrote and moderated It's Your Business, a nationally syndicated debate program on economic, business, and political issues that aired weekly on 140 network affiliates and independent stations. She also co-anchored Nation's Business Today for six years on ESPN.

Concurrent with her broadcast responsibilities, Meryl Comer served for 11 years (1987-1997) as Vice President for Communications Development at the U.S. Chamber of Commerce. In that position, Comer managed the U.S. Chamber's first major institutional advertising campaign, designed and produced a long-running business-education TV series with BellSouth and Junior Achievement, served as executive producer and moderator of QLS management training satellite seminars (over 100 to date), developed broadcast partnerships and joint ventures, and hosted numerous Satellite Town Hall Specials.

Prior to joining the broadcast division of the U.S. Chamber of Commerce full-time in 1983, Meryl Comer was VP of Broadcast for the Washington public relations firm Gray and Company, now Hill & Knowlton. In 1981, she worked as the Network Press Liaison for the Reagan-Bush Inaugural Committee.

Between 1978 and 1979, Meryl Comer hosted the daily talk show Good Day! on WCVB-TV, the ABC affiliate in Boston. Prior to that, she was producer and host for the popular interview show 2's Company on WMAR-TV, the CBS affiliate station in Baltimore, from 1976 to 1978. From 1974 to 1976, Meryl Comer co-anchored the Ten O' Clock News for WTTG Television, formerly the Metromedia outlet in Washington, now a Fox Television station. Previously, Comer served as co-host of Metromedia's daily 3-hour talk show, Panorama, and as associate feature editor of the Philadelphia Inquirer.

Meryl Comer is a member of the board of directors for Carnival Hotels & Casinos International, Inc., CHC Canada, LTD. (Audit Committee member), the Eureka Foundation, and The National Foundation for Advancement in the Arts, for which she also serves on the Board of Trustees, Executive Committee, and Presidential Search Committee. She is on the advisory boards of Women in Washington, Board of Governors, The National Women's Economic Alliance Foundation, CIPE (Center For International Private Enterprise). Her past board affiliations include The Fulbright 50th Anniversary Committee (USIA '95/96), The President's Advisory Council on Physical Fitness and Sports ('84-86) and White House Fellows Program ('75).